Mouse Models

The following mouse strains may be of interest to the dysferlin research community. Please feel free to contact the Jain Foundation for more information or with specific questions about working with these strains.
  • Bla/J mice (B6.A-Dysfprmd/GeneJ)
    A backcrossed strain of mice carrying the A/J dysferlin mutation on the C57BL/6 background.
  • A/J mice
    A naturally-occurring dysferlin-deficient strain of mice with a retrotransposon insertion in dysferlin intron 4.
  • C57BL/6J-Chr6A/J/NaJ mice
    A chromosome substitution strain of mice carrying chromosome 6 (including dysferlin) from the A/J strain on the C57BL/6 background.
  • SCID/AJ mice
    A backcrossed strain of mice carrying the A/J dysferlin mutation on the SCID background.
  • Dysf-/- mice (B6.129‐Dysftm1Kcam/J)
    A knockout strain of mice in which dysferlin exons 53-55 (the C terminus) have been deleted on a mixed 129SvJ and C57BL/6 background.
  • SJL/J mice
    A naturally-occurring dysferlin-deficient strain of mice with a deletion of dysferlin exon 45.
  • B10.SJL‐Dysfim/AwaJ mice
    A backcrossed strain of mice carrying the SJL/J dysferlin mutation on the C57BL/10 background.